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Index > Protein center > CD84(Gene name) > Human
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  • CD84 (Gene name),
  • SLAM family member 5 (Protein name ),  SLAF5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CD84(SLAMF5);
    Protein name:
    SLAM family member 5;
    Alternative:
    Hly9-beta;Cell surface antigen MAX.3;Signaling lymphocytic activation molecule 5;Leukocyte differentiation antigen CD84;
    CD:
    CD84;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; via its extracellular domain. Forms a head to tail dimer with a CD48 molecule from another cell. Interacts with SH2 domain-containing proteins SH2D1A/SAP and SH2D1B/hEAT-2. Interacts with tyrosine-protein phosphatases PTPN6 and PTPN11 via its phosphorylated cytoplasmic domain, and this interaction is blocked by SH2D1A.
    Function:
    Plays a role as adhesion receptor functioning by homophilic interactions and by clustering. Recruits SH2 domain-containing proteins SH2D1A/SAP. Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    345
    Sequence:
    50:
    MAQHHLWILL | LCLQTWPEAA | GKDSEIFTVN | GILGESVTFP | VNIQEPRQVK | 
    100:
    IIAWTSKTSV | AYVTPGDSET | APVVTVTHRN | YYERIHALGP | NYNLVISDLR | 
    150:
    MEDAGDYKAD | INTQADPYTT | TKRYNLQIYR | RLGKPKITQS | LMASVNSTCN | 
    200:
    VTLTCSVEKE | EKNVTYNWSP | LGEEGNVLQI | FQTPEDQELT | YTCTAQNPVS | 
    250:
    NNSDSISARQ | LCADIAMGFR | THHTGLLSVL | AMFFLLVLIL | SSVFLFRLFK | 
    300:
    RRQGRIFPEG | SCLNTFTKNP | YAASKKTIYT | YIMASRNTQP | AESRIYDEIL | 
    345:
    QSKVLPSKEE | PVNTVYSEVQ | FADKMGKAST | QDSKPPGTSS | YEIVI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human SLAM family member 5
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    E9091h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human SLAM family member 5
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    E9091m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human SLAM family member 5
    Cat.:
    U9091h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human SLAM family member 5
    Cat.:
    U9091m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human SLAM family member 5
    Cat.:
    P9091Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human SLAM family member 5
    Cat.:
    P9091Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human SLAM family member 5
    Monoclonal Antibody for Human SLAM family member 5
    Protein for Human SLAM family member 5
    Protein for Human SLAM family member 5

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    Recovery
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    Linearity
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    References
    1. 1.
      "CD84 leukocyte antigen is a new member of the Ig superfamily."
      de la Fuente M.A. , Pizcueta P. , Nadal M. , Bosch J. , Engel P.
      Blood90:2398-2405(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);GLYCOSYLATION;TISSUE SPECIFICITY
    2. 2.
      "Characterization of MAX.3 antigen, a glycoprotein expressed on mature macrophages, dendritic cells and blood platelets: identity with CD84."
      Krause S.W. , Rehli M. , Heinz S. , Ebner R. , Andreesen R.
      Biochem. J.346:729-736(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);PROTEIN SEQUENCE OF 22-35;GLYCOSYLATION;TISSUE SPECIFICITY
    3. 3.
      "Genomic characterization of CD84 reveals the existence of five isoforms differing in their cytoplasmic domains."
      Palou E. , Pirotto F. , Sole J. , Freed J.H. , Peral B. , Vilardell C. , Vilella R. , Vives J. , Gaya A.
      Tissue Antigens55:118-127(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6)
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 7)
      tissue: Thalamus.
      tissue: Umbilical cord blood.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7)
      tissue: Semen.
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Lymph.
    10. 10.
      "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP."
      Sayos J. , Martin M. , Chen A. , Simarro M. , Howie D. , Morra M. , Engel P. , Terhorst C.
      Blood97:3867-3874(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;SUBCELLULAR LOCATION;INTERACTION WITH SH2D1A AND PTPN11
    11. 11.
      "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family."
      Lewis J. , Eiben L.J. , Nelson D.L. , Cohen J.I. , Nichols K.E. , Ochs H.D. , Notarangelo L.D. , Duckett C.S.
      Clin. Immunol.100:15-23(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6 AND PTPN11
    12. 12.
      "CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A."
      Shlapatska L.M. , Mikhalap S.V. , Berdova A.G. , Zelensky O.M. , Yun T.J. , Nichols K.E. , Clark E.A. , Sidorenko S.P.
      J. Immunol.166:5480-5487(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN ITSM MOTIF
    13. 13.
      "CD84 functions as a homophilic adhesion molecule and enhances IFN-gamma secretion: adhesion is mediated by Ig-like domain 1."
      Martin M. , Romero X. , de la Fuente M.A. , Tovar V. , Zapater N. , Esplugues E. , Pizcueta P. , Bosch J. , Engel P.
      J. Immunol.167:3668-3676(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;HOMODIMERIZATION;FUNCTION
    14. 14.
      "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2."
      Tangye S.G. , van de Weerdt B.C.M. , Avery D.T. , Hodgkin P.D.
      Eur. J. Immunol.32:1640-1649(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;DEVELOPMENTAL STAGE;INTERACTION WITH SH2D1A AND SH2D1B
    15. 15.
      "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation."
      Tangye S.G. , Nichols K.E. , Hare N.J. , van de Weerdt B.C.M.
      J. Immunol.171:2485-2495(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;MUTAGENESIS OF TYR-279 AND TYR-316
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    17. 17.
      "Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)."
      Romero X. , Benitez D. , March S. , Vilella R. , Miralpeix M. , Engel P.
      Tissue Antigens64:132-144(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    18. 18.
      "Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling."
      Nanda N. , Andre P. , Bao M. , Clauser K. , Deguzman F. , Howie D. , Conley P.B. , Terhorst C. , Phillips D.R.
      Blood106:3028-3034(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT TYR-296 AND TYR-316;IDENTIFICATION BY MASS SPECTROMETRY
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 22-131;SUBUNIT;MUTAGENESIS OF THR-55; TYR-62; THR-77; HIS-78; ASP-110; ASN-112 AND THR-119
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